Check point inhibitors, such as anti- programmed death 1 (PD-1) (Nivolumab, Pembrolizumab)/ anti-programmed death-ligand 1 (PD-L1) therapies (Atezolizumab, Avelumab and Durvalumab) have dramatically changed the therapeutic and prognostic landscape for several types of malignancy. These agents provide significant survival benefits in many cancers, but the...
Accelerated approval to Polivy (Polatuzumab vedotin), in combination with the chemotherapy bendamustine and rituximab (P-BR) by the U.S. FDA for the treatment of patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL), indicates the unmet need and necessity of newer therapies for the...
Recommendations of an Oncology Drugs Advisory Committee (ODAC) against approval of Quizartinib further opened debate on effective end point for registration studies of acute myeloid leukemia (AML). Though, the Study AC220-007 showed encouraging results a statistically significant improvement in overall survival (OS) with Quizartinib as...
Eboigbodin K.E. et al., Diagnostic Microbiology and Infectious Disease, 2016 Recent worldwide large outbursts of the ZIKV necessitate the availability of a rapid, cost-effective and quick diagnostic method for ZIKV detection. Conventional diagnostic methods rely upon serological methods or nucleic acid amplification tests (NAATs), both of...
Salje H. et al., PNAS, 2016 Contraction of the disease during an infectious disease epidemic is dependent on interrelated factors, that may be directly related to the individual (age, sex), his family or the wider community of which he is a part. Advances in statistical modelling...
Lebel C. et al., Biological Psychiatry, 2016 It is well- known that perinatal maternal depression is a serious health concern, with its negative effects lasting on children. Prenatal depression is associated with altered brain gray matter in children, though the relation between postpartum depression, children’s brains...